Effect Of Palm Oil (Elias Guinensis) Leaf Standardized Extract On Progression Of Renal Dysfunction And Arterial Stiffness In Normal And High Fat Diet Fed Sprague Dawley Rats With Induces Nephrotoxicity

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Date
2011
Authors
Ibraheem, Zaid O.
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Universiti Sains Malaysia
Abstract
Saturated free fatty acids (SAFFAs) trigger their deleterious effects through inducing the intracellular inflammatory pathway related to insulin resistance. This results in a constellation of biomedical disorders known as metabolic syndrome. Gentamicin is a widely used aminoglycoside antibiotic. Its nephrotoxic action is characterized by both proximal convoluted tubules and glomerular membrane damage. The mechanism of nephrotoxicity is closely related to oxidative stress and free radicals generation. It is found nowadays that palm oil leaf extract has got some biomedical importance due to its content of polyphenols which act to counteract the oxidative stress. Our study aimed to find the impact of replacing the essential dietary elements in food by SAFFAs enriched fats on progression of renal damage and its associated hemodynamic and metabolic changes in rat's model of gentamicin induced nephrotoxicity. The study also evaluated the prophylactic effect of palm oil leaf extract (POLE) on progression of these disorders. Renal dysfunction was assessed through measuring serum creatinine, creatinine clearance, fractional and absolute excretion of both sodium and potassium, malonyldialdehyde (a biomarker of oxidative stress) in renal homogenate and the urinary protein excretion. The results showed a higher incidence of nephrotoxicity in the rats fed with the diet enriched with SAFFAs as compared to those fed with the standard diet. The nephrotoxicity was graded as mild for the renal failure group fed with the standard diet and moderate to severe for those fed with the SAFFAs enriched diet. High dose of POLE could have limited the progression of nephrotoxicity and oxidative stress development in the renal tissue. Metabolic syndrome was assessed through performing oral-glucose tolerance test (OGTT), measuring the lipid profile and obesity indices.
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Evaluated the prophylactic effect of , the prophylactic effect of palm oil leaf extract
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