Contribution of u1-adrenoceptor subtypes in renal hemodynamics and functions of rats with renal imparment:Alteration of G-protein linked to shift in the functionality and expression of renal a1 andrenoceptor subtypes.
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Date
2013
Authors
Abdul Sattar, Munavvar Zubaid
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Abstract
This study investigated the role of a 1-adrenoceptors subtypes in the regulation of renal
haeamodynamics at the level of renal resistance vasculature. It is hypothesized that a 1-
adrenoceptor subtype(s) distribution depends on pathophysiological states of animal. Thus, the
functional role of a 1-adrenoceptor subtype(s) on renal haeamodynamics of rats with renal failure,
diabetic nephropathy and cardiac hypertrophy was investigated along with the Go proteins
expression in the kidney and heart of normal rats and that of rats with impairments.
Description
Keywords
a-adrenoceptors , G-proteins , Heart failure