Role of Positron Emission Tomography with Computed Tomography using F-18 Flurodeoxyglucose in detection of Carcinoma of Unknown Primary in Malaysia
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Date
2016
Authors
Samsudin, Nursazlinda
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Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Carcinoma of unknown primary represents a heterogenous group of tumour with well known characteristics and behavior. It is essential to locate the primary tumor to facilitate specific treatment for patients. It is said that conventional investigations may detect the primary in about 30% of patients diagnosed with this condition. F-18- flurodeoxyglucose PET-CT has been used to detect the primary tumor when conventional methods fail. This study retrospectively investigates the role of F-18-flurodeoxyglucose in detection of primary in Carcinoma of Unknown Primary in Malaysia. We found that F-18-flurodeoxyglucose PET-CT localised the primary in 40% of patients, has a sensitivity of 76.67%, specificity of 92.11% and positive predictive value of 88.46%. The most common site of the primary is the lung, followed by the ovaries and the pancreas.
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Keywords
Role of Positron Emission Tomography , with Computed Tomography using F-18