Inhibition of microlax- Induced experimental diarrhoea with narcotic like-extracts of psidium guajava leaf in rats
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Date
1999
Authors
Lutterodt, George D.
Journal Title
Journal ISSN
Volume Title
Publisher
Kampus Kesihatan, Universiti Sains Malaysia
Abstract
Measurement of rates of propulsion in the small intestine in control and experimental groups of male Sprague-Dawley rats (200-250 g) were carried out as a means of assessing antidiarrhoeal activity of aqueous extracts of the leaf of Psidium guajava (Linn.), using morphine as the standard drug of reference. Hyperpropulsion (diarrhoea) was induced by gavaging rats in_a control group with Microlax, using phenol red mixed .into it as a marker in the intestine,. and the mean rate of the hyperpropulsion was determined. The normal rate of propulsioh, defined as the percentage of the length of the ileum traversed by the front of the dye in 1 h after gavaging animals with a liquid paraffin-phenol red meal, was also determined in another control group.
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Keywords
Psidium guajava , Diarrhoea