Kajian mengenai profil kontraseptif sediaan herba tradisional orang asli kaum temuan

Loading...
Thumbnail Image
Date
2004
Authors
Sulaiman, Siti Amrah
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Research and development to seck for new contraceptives are necessary to fullfill the requirement of the population at large. Studies to authenticate and evaluate three herbal contraceptives belonging to Orang Asli Temier Group were performed. The herbs were Lepidagathis longifolia (PI), Palaquiwn sp. (P2) dan Phyllagathis rotundifo/ia (P3). Traditionally, a combination decoction of the three plant species was consumed monthly for three to five consecutive days before the commencement of each anticipated menstrual period or the individual plant species could be consumed daily. The water-based extract of the combined herbal formulation (EP 123) and the individual plants (EP 1, EP2 and EP3) were given to pregnant, pseudo-pregnant and non-pregnant rats. The comQined herbal extract (EP123) caused reduction in maternal body weight, fetal resorption, fetal death, prolongation of duration of pregnancy and failure of delivery. No teratogenic effects were observed. EP 123 significantly reduced plasma estradiol concentration and inhibited decidual formation in pseudo-pregnant rats. EP1, EP2 and EP3 did show a similar effect, however they were less potent compared to EP 123. The herbal extracts caused anovulatory and prolongation of estrus cycle. EP 123 reduced the estradiol, progesterone, FSH and LH concentrations. EPl and EP2 reduced the estradiol while maintaining progesterone concentrations. EP3 reduced estradiol concentration but increased the progesterone concentration. The ratios of estradiol : progesterone concentration were reversed, mimicking a pseudo-pregnancy state. Histological examination of the uterus revealed the presence of copora lutea and atretic ova. The ratios of uterine endometrial : muscular thickness were increased and peaked in animals that received EP3. The cell density and mean cell area of the folliculotroph were reduced in herbal treated anill)als. The anovulatory cycle was a reversible phenomena upon cessation of treatment, however ·the recovery was slow. Administration of eCG followed by hCG stimulated ovulation in all EP 123 treated animals. These findings supported Lhe use of the three herbs as contraceptive and the possible mode of action was through .the mimicking of a pseudo-pregnancy state in non-pregnant rats. Current findings suggested that P3 was the best candidate for contraceptive development. P3 has a strong antiestrogenic and progestrogenic effects. EP 123 was a potent anti estrogenic and a weak progestrogenic agent. The administration of EP 123 before each mensus can reveal its abortifacient properties.
Description
Keywords
Herba tradisional , Kontraseptif
Citation