Evaluation Of Coronary Heart Disease Risk Among Patients With Type 2 Diabetes In Hospital Pulau Pinang, Malaysia
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Date
2011-07
Authors
Majeed, Saif Aldin R. Abdul
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
The prevalence of diabetes mellitus had increased tremendously in the Malaysian population during the last decade. In addition to that, cardiovascular disease (CVD) reported to be an important cause of morbidity and mortality in Malaysia. Patients with diabetes are more likely to develop coronary heart disease (CHD) than a non diabetic population. Moreover, patients with diabetes but without clinical evidence of CHD own the same risk for CHD events as patients without diabetes but with CHD. The classical risk factors for CHD play an important role in the CHD risk estimation among patients with diabetes. These risk factors are age, gender, smoking status, hyperglycaemia, hypertension, dyslipidaemia and obesity. The prediction of CHD goes back to the development of epidemiological and biostatistical methods. The United Kingdom Prospective Diabetes Study (UKPDS) risk engine incorporates mathematical equations into a model which calculates the absolute risk of incident cardiovascular disease (CVD). The UKPDS risk calculator is used specifically for patients with type 2 diabetes. Furthermore, it includes glycated haemoglobin (HbA1c) as a continuous variable and the time since diagnosis of diabetes.
This research aimed to estimate the predicted 10-year CHD risk among patients with type 2 diabetes using the diabetes specific UKPDS risk engine calculator and the factors associated with it. It also examined the target outcome for the CHD risk factors according to the Malaysian Diabetes Guideline. Finally, it investigated the
association of glycaemic control with CHD risk. To achieve this, a retrospective cross sectional study was conducted at the Outpatient Diabetes Clinic in Hospital Pulau Pinang. The patients included in the study were diagnosed with type 2 diabetes, between 25-65 years; their diabetes duration was between 1-20 years. The study excluded patients with the history or with family medical history of CHD and patients with gestational diabetes. One thousand patients (529 male) were recruited in the study. The 10-year predicted CHD risk was calculated using the UKPDS risk engine.
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Keywords
Evaluation of coronary heart disease risk , among patients with type 2 diabetes