PROGNOSTIC FACTORS OF PATIENTS WITH ACINETOBACTER BAUMANNII BACTEREMIA NOSOCOMIAL INFECTION IN HOSPITAL UNIVERSITI SAINS MALAYSIA
| dc.contributor.author | NUR SOPHIA, RUSLI | |
| dc.date.accessioned | 2017-10-31T03:34:48Z | |
| dc.date.available | 2017-10-31T03:34:48Z | |
| dc.date.issued | 2012 | |
| dc.description.abstract | INTRODUCTION: Acinetobacter baumannii has emerged as an important and problematic human pathogen as it is the causative agent of several type of infection including bacteremia. The research finding on the prognostic factors obtained are expected to help in management the Acinetobacter baumannii nosocomial infection and improving the survival rate. OBJECTIVES: The objectives of this study are to determine the median survival time of patient with Acinetobacter baumannii bacteremia nosocomial infection, and to identify the prognostic factors that influenced the mortality among patients with Acinetobacter baumannii bacteremia infection. METHODOLOGY: A retrospective record review was conducted involving 130 patients of bacteremia infected with Acinetobacter baumannii in HUSM, from 1st January 2010 to 31st December 2011. All patients who fulfilled the inclusion and exclusion criteria were included in the study. Additional follow up was done from 1st January 2012 until 31st January 2012 (1 month). All the important information on the variables interest and patients’ survival status until 31st January 2012 were collected and recorded into data collection form. Kaplan Meier estimator, simple and multiple Cox Proportional Hazard regression were performed to determine the median survival and statistical significance of the prognostic factors. RESULTS: A total of 67 (51.5%) patients died in this study. The overall median survival time for patient with Acinetobacter baumannii bacteremia in this study was 40 days (95% CI: 31.33, 44.99). After adjusting for other variables, the significant prognostic factors that influenced the mortality of Acinetobacter baumannii nosocomial bacteremia in this study were mechanical ventilation (HR= 57.18; 95% CI: 7.79, 419.66; p-value <0.001) and antibiotic susceptibility (HR= 3.15, 95% CI: 1.69, 5.88; p-value <0.001). CONCLUSION: The median survival time for patient with Acinetobacter baumannii bacteremia in the study was higher (40 days) compared to the previous study. Patients with A. baumannii bacteremia who needed mechanical ventilation and resistant to antibiotics were at higher risk of death compared with those who did not need mechanical ventilation and susceptible to antibiotics. However, other potential prognostic factor such as invasive procedure, presence of neutropenia, and renal failure were not identified as the significant prognostic factor in this study. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/5188 | |
| dc.language.iso | en | en_US |
| dc.publisher | Pusat Pengajian Sains Perubatan Universiti Sains Malaysia | en_US |
| dc.subject | Medical Statistics | en_US |
| dc.title | PROGNOSTIC FACTORS OF PATIENTS WITH ACINETOBACTER BAUMANNII BACTEREMIA NOSOCOMIAL INFECTION IN HOSPITAL UNIVERSITI SAINS MALAYSIA | en_US |
| dc.type | Thesis | en_US |
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