Chemical and pharmacological characterisation of some traditional remedied used by bomoh's in the management of drug addiction
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Date
1980-01
Authors
Yunus, Amiru'd-Din
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
In the present investigations, the samples obtained from Bomohs were examined tor their properties which were claimed that can be used in the management of narcotic addiction. These were studied from various aspects of the narcotic addiction in the mice. All together six samples were studies and were labelled as Sample I, Sample n, Sample III, Sample IV, SUple V and Sample VI. Morphine tolarence in mice were induced by a single dose as described by Jacob J.J. et. al., (1972, 1974). The precipitated withdrawal anydromes were induced using nalorphine, the narcotic antagonist. Both samples I and II are able to supress the precipitated withdrawal jumping in mice and the most probable pathways are via dopaminergic system. The rest ot the samples are not able to supress the precipitated withdrawal jumping in mice. Analgesia property of the samples are evaluated using the modified hot plate method. This assessment are baeed on the reaction time shown by the mice. Tho results indicated that the
analgesia properties of the samples are varies from one to another. Sample I has longer time of the analgesia property of morphine, Samples II and III about the same of analgesia time of morphine. Samples IV and V having shorter analgesia time compared to morphine, and Suple VI has less or no effect on analgesia time of morphine. General behaviours or the mice treated with the samples also examined. This make use of hole-board test whereby the number of crossings, the number of dippings and the number or preens were avaluated. Besides this, the. sponteneous motor activity also assessed using the animex activity mater. All the samples tested are capable or increasing the exploratory behaviours which were lowered by the morphine. The spontaneous motor activity on the other hand, were decreased in the presence of these samples. Thus, the raising in spontaneous motor activity caused by morphine will be decreased by all the samples. Body (rectal) temperature of the mice were examined
using . the tale-thermometer. Morphine will cause the lowering of the body temperature. On examination of the Samples - all of them are capable of increasing the body temperature of the mice. All the samples also elevated the respiratory despression caused by the morphine. The state of alertness and irritability
also increase in the presence of all these samples. None or the samples contain opiates, tropane alkalold,
rowalfia alkaloid {reserpine), ergotamine and yohimbine.
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