The impact of a moderate exercise programme on serum interleukin-2 and interleukin-4 levels among secondary school children
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Date
2001-05
Authors
Mat Ludin, Arimi Fitri
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Cytokines are soluble glycoproteins that mediate cotntnunication between and within
imn1une and non-imtnune cells. An alteration of cytokine production will impair the
i1nrnune response and function. Previous studies on the itnpact of exercise on cytokines
have not been conclusive. Most studies were centered on adults and there is a lack of data
about the correlation between exercise and cytokines on adolescents. The purpose of this
investigation therefore, was to detennine the effect of tnoderate exercise on some
cytokine levels in adolescence.
Thirty five (n=35) physically inactive 16 year old boys were recruited and subjected to a
tnoderate exercise, 60 - 75% of 1naxHR, 40 - 60 tnin. duration, 3 times/week, for eight
(8) weeks. They were subjected to the fitness test ( one-tnile run test) also 10 ml of blood
was drawn for differential count and the serutn (50 Jll) for IL-2 and IL-4 analysis using
ELISA for both pre and post-exercise progra1nn1es. Data collected were analysed by the
Student's paired t-test. There was 110 significant difference in scnnn I L-2 and I L-4 levels as well as in total and
differential white blood cell counts. llowever, there were significant (p<0.05)
improvements in the one-tnile run tests. (9.07 ± 0. 11 tnin. vs. 9.0 I ± 0.11 n1in. ) .. resting
heart rate (68.63 ± 0.42 beats/tnin. vs. 64.83 ± 0.29 beatsltnin. ), blood pressure ( 115.00 ± 1.47 tnmflg vs. 110.77 ± 1.36 rnmHg for systolic and 68.26 ± 1.15 mmHg vs. 67.17 ±
0.97 mml-lg for diastolic), RBC count (5.00 ± 0.06 x 109/1 vs. 5.14 ± 0.06 x 109/1)~
haemoglobin concentration ( 14.35 ± 0.15 mg/d1 vs. 14.63 ± 0.15 tng/dl) and haematocrit
(42.20 ± 0.42% v.s. 42.95 ± 0.39).
The study indicates that tnoderate exercise progran11ne could itnprove the fitness level in
the adolescent with no alteration in IL-2 and IL-4 levels.
Description
Keywords
Serum interleukin-2 and interleukin-4