Development and evaluation of a matrix controlled release implant system for testosterone
| dc.contributor.author | Hamad, Islam | |
| dc.date.accessioned | 2015-07-30T04:00:50Z | |
| dc.date.available | 2015-07-30T04:00:50Z | |
| dc.date.issued | 2002 | |
| dc.description.abstract | Implant systems fabricated using hydroxypropyl methylcellulose (HPMC KIOO) and . starch at a ratio of 9: 1 were smooth and uniform in shape with adequate hardness. Starch was added in low concentrations to facilitate the extrusion of the implant system. The implant systems also displayed a controlled release of testosterone, which could be varied in a predictable manner bY varying the'drug to polymer ratio. rhe effect of different viscosity grades of HPMC and the addition of anionic surfactant m the release profile of the implant systems were also evaluated. Higher viscosity grades ,f HPMC and the addition of sodium Iaury! sulphate (SLS) were capable of further etarding the release of testosterone from the implant system. 'wo formulations of the implant systems were further evaluated in an in-vivo study using -velve Sprague Dawley (SD) male rats. Both formulations contained 10 mg of :stosterone with drug to polymer ratios of 8: 2 and 4: 6. A slow and sustained release of :stosterone was observed after the implantation and during the entire study period. The :te of testosterone release from implant system with 8: 2 drug to polymer ratio was >proximately two times higher than that with 4: 6 drug to polymer ratio; thus indicating at the release was highly correlated with the polymer content in the formulation as well the in-vitro dissolution results. Moreover, plasma testosterone levels throughout the 24 hours were reasonably constant throughout the day period. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/984 | |
| dc.language.iso | en | en_US |
| dc.subject | Matrix controlled | en_US |
| dc.subject | Testosterone | en_US |
| dc.title | Development and evaluation of a matrix controlled release implant system for testosterone | en_US |
| dc.type | Thesis | en_US |
Files
License bundle
1 - 1 of 1
Loading...
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: