The Clinical Significance Of Npm1, Flt3 And Cebpa Gene Mutations In Adult Patients With Acute Myeloid Leukaemia

dc.contributor.author	Izaz Ul Haq
dc.date.accessioned	2022-03-31T07:02:01Z
dc.date.available	2022-03-31T07:02:01Z
dc.date.issued	2020-11
dc.description.abstract	Acute myeloid leukaemia (AML) is a biologically complex and clinically heterogeneous haematological cancer, and its incidence increases in the elderly. Age, cytogenetics and genetic mutations remain important prognostic factors for treatment outcome. The main aim of the study was to determine the prevalence and clinical significance of NPM1, FLT3 and CEBPA mutations of AML in the Peninsula Malaysia. Three common and important gene mutations in AML FLT3 (exon 14-15, exon 20), NPM1 (exon 12), and CEBPA (exon 1) were determined by polymerase chain reaction and conformation-sensitive gel electrophoresis (CSGE) in 47 newly diagnosed adult patients with AML. Fisher-Exact Test was used to analyse the significant difference of AML with FLT3-ITD, NPM1, and CEBPA mutants in association with the clinical parameters.	en_US
dc.identifier.uri	http://hdl.handle.net/123456789/15003
dc.publisher	Universiti Sains Malaysia	en_US
dc.subject	Clinical Significance Of Npm1, Flt3 And Cebpa Gene Mutations	en_US
dc.subject	Adult Patients With Acute Myeloid Leukaemia	en_US
dc.title	The Clinical Significance Of Npm1, Flt3 And Cebpa Gene Mutations In Adult Patients With Acute Myeloid Leukaemia	en_US
dc.type	Thesis	en_US

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