Virtual high throughput screening for avian Influenza (H5N1) neuraminidase inhibitors.
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Date
2011-07
Authors
Ismail, Nurul Izza
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
H5N1 adalah satu daripada sub-jenis virus influenza yang boleh menyebabkan ancaman pandemik bukan sahaja kepada burung, tetapi juga kepada kebanyakan spesis lain termasuk manusia. Neuraminise N1 adalah enzim glikoprotein yang terdapat dipermukaan partikel virus influenza.
Avian influenza H5N1 virus which caused virulent influenza in birds is a pandemic threat causing viral disease in many species including humans. Neuraminidase N1, an antigenic glycoprotein enzyme found on the surface of the influenza particle, was chosen as a drug target for virtual high-throughput drug screening of small molecules that is capable of blocking its activity.
Description
Keywords
Screening , Influenza