Bio-Topology-Based multi-objective meta-heuristic for reconstruction of metabolic and protein-protein interaction networks
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Date
2020-03
Authors
Dael Naef, Ahmed Abdulglil
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Publisher
Universiti Sains Malaysia
Abstract
In this thesis, we utilize the structural properties of scale-free networks and the biological knowledge about individual genes and proteins to recontruct metabolic networks represented as enzyme graph and protein interaction networks. A multi-objective optimization based method has been proposed which uses the structural properties of scale free networks and the biological knowledge. We tested our method on four commonly-used protein networks in yeast. Two datasets are networks related to the metabolism of the yeast: KEGG and BioCyc. The other two datasets are networks from protein-protein interaction: Krogan and BioGrid.
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Keywords
Bio-Topology-based multi-objective meta- , for reconstruction of metabolic and protein-protein interaction networks