Bio-Topology-Based multi-objective meta-heuristic for reconstruction of metabolic and protein-protein interaction networks

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dc.contributor.authorDael Naef, Ahmed Abdulglil
dc.date.accessioned2022-06-08T03:24:00Z
dc.date.available2022-06-08T03:24:00Z
dc.date.issued2020-03
dc.description.abstractIn this thesis, we utilize the structural properties of scale-free networks and the biological knowledge about individual genes and proteins to recontruct metabolic networks represented as enzyme graph and protein interaction networks. A multi-objective optimization based method has been proposed which uses the structural properties of scale free networks and the biological knowledge. We tested our method on four commonly-used protein networks in yeast. Two datasets are networks related to the metabolism of the yeast: KEGG and BioCyc. The other two datasets are networks from protein-protein interaction: Krogan and BioGrid.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/15367
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectBio-Topology-based multi-objective meta-en_US
dc.subjectfor reconstruction of metabolic and protein-protein interaction networksen_US
dc.titleBio-Topology-Based multi-objective meta-heuristic for reconstruction of metabolic and protein-protein interaction networksen_US
dc.typeThesisen_US
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