Formulation And Evaluation Of Channa Striatus Extract And Fusidic Acid Aerosol For Treatment Of Wounds And Burn
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Date
2011
Authors
Febriyenti
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Aerosol is a new drug delivery system for wound dressing and wound treatment. Aerosol has several benefits when compared with other delivery systems such as plasters or bandages for wound dressing and cream or gel for wound treatment. When applied to the body aerosol reduces pain that may result from the mechanical rubbing of gel and creams onto the skin. Aerosol could cover any size of wound which could not be covered by films due to films have a fixed size. Channa striatus has been used since a long time ago traditionally to accelerate the wound healing. Channa striatus extract contained amino acids and fatty acids which important for healing process. Fusidic acid is an antimicrobial for topical application. Channa striatus extract and in combination with fusidic acid have been used as active ingredients in this study. Channa striatus extract contained about 3.61% protein. HPLC systems for amino acids analysis and GC systems for fatty acids analysis method used in this study met the requirements of validation. These HPLC systems are reliable and reproducible. Channa striatus extract contained amino acids that could promote the wound healing process. Channa striatus extract also contained omega-3 and omega-6 that are very important in wound healing process. Ratio between omega-3 and omega-6 fatty acids was 0.85. Omega-6 fatty acid is needed as inflammatory inducer in the early phase of wound healing process. HPMC is the best among polymers tested to produce concentrate for aerosols and films with the expected qualities. Glycerine has been used as plasticizer for formula E and PEG 400 for formula G. Tocopherol was used as antioxidant. Aerosol aluminium can was used as container. Based on safety and economic aspect, butane was chosen to be used as the propellant for Channa striatus and fusidic acid aerosols.
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Keywords
Aerosol is a new drug delivery system , for wound dressing and wound treatment