Association Of Mitochondrial Dna 10398 Polymorphism With Breast Cancer And Apoptosis In Malay Population
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Date
2011-07
Authors
Tengku Baharudin Shah, Tengku Puteri Nadiah
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
The mitochondrial DNA 10398 polymorphism has been observed to associate with
breast cancer in several populations. In this study, mitochondrial DNA 10398 polymorphism
was screened in 101 Malay female patients with invasive breast cancer and 90 age-matched
healthy female controls using minisequencing method. The results showed a statistically
significant difference with P value of p = 0.007 (OR, 2.29; 95% CI, 1.252-4.200) with the
proportion of G variant was higher (73%) than A variant in patients (27%) as well as in
controls (G = 54%, A = 46%). The breast cancer tissues were then analyzed using
immunohistochemistry method to investigate the relation of this polymorphism in affecting
apoptotic level in breast cancer. No significant difference was observed between the
expression of pro (Bax) and anti-apoptotic (Bcl-2) proteins among patients carrying A
variant (p = 0.48). However, significant difference was observed in patients with G variant
(p = 0.016). These results indicate that mtDNA 10398 polymorphism may be useful as a
breast cancer risk marker in this population.
Description
Keywords
Mitochondrial Dna 10398 Polymorphism , Breast Cancer And Apoptosis