Antibacterial, Antioxidant And Platelet Boosting Properties Of Semalu And Manna Plus Extracts
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Date
2016-07
Authors
Bendran, Akash Parthi
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Abstract
Semalu and Manna Plus are commercial products known for their medicinal values such as boosting immunity, natural mild antibiotic, protein metabolism and balancing homeostasis. The proponents or consumers of these products claim that they are efficient in boosting platelets in dengue acquired patients. In view of this some pharmacological properties of these extracts such as, cytotoxicity, antioxidant, antibacterial and platelet boosting effect were undertaken. HPTLC methods were successfully developed for phytochemical analysis of eugenol, curcumin, linoleic acid and quercetin respectively for quantification and quality control purposes. Standardized extracts of semalu and manna plus were employed for all pharmacological evaluations. The cytotoxicity results demonstrated manna plus and semalu methanolic and ethanolic extracts exhibited nontoxic effects at <620 μg/mL on Chang HeLa cells. With regards to antimicrobial activity, semalu and manna plus ethanolic extracts were active against S. aureus, B. subtilis and P. aeruginosa (MIC: 125-250 μg/mL). However water extracts showed inhibition only against gram positive (MIC: 250 μg/mL) bacteria. Semalu and manna plus ethanolic and methanolic extracts demonstrated antioxidant activity (DPPH: TE/g: 452.8 ± 1.1 -126.6 ± 2.0 mg; TPC: GAE/g: 153.7 ± 0.05 – 41.5 ± 0.02 mg; FRAP: TE/g: 192.49 ± 3.1 - 20.30 ± 2.0 mg). With reference to platelet boosting properties ethanolic extracts demonstrated platelet boosting effects in thrombocytopenia induced rats. The platelet boosting effects of these extracts (5 mg/kg) are comparable to that of papaya extract (500 mg/kg). In summary, the antioxidant, antibacterial and platelet
boosting properties of semalu and manna plus may provide some scientific evidence for its usage as supplement for various ailment including dengue.
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The antioxidant, antibacterial and platelet xxvi boosting properties of semalu and manna plus , provide some scientific evidence for its usage as supplement for various ailment including dengue.