Effects of cross-fostering and melatonin supplementation on the development of hypertension and renal antioxidant/oxidant system in spontaneously hypertensive rats.
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Date
2011-08
Authors
Siew Keah, Lee
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Journal ISSN
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Publisher
Universiti Sains Malaysia
Abstract
Pelbagai intervensi di awal hayat SHR telah dilakukan dalam percubaan untuk memprogram semula profil peningkatan tekanan darah dalam SHR tetapi manfaatnya adalah terhad dan sementara sahaja. Kajian ini memeriksa kesan peliharaan silang, pemberian melatonin semasa antenatal dan postnatal atau kombinasi kedua-duanya ke atas perkembangan hipertensi dan system antioksidan/oksidan ginjal dalam tikus SHR dan WKY.
Various interventions in early life in SHR have been attempted to reprogramme the raised blood pressure profile in SHR but with limited and only transient benefits. This study examined the effects of either cross-fostering or antenatal and postnatal melatonin supplementation alone or in combination on the development of hypertension and renal antioxidant/oxidant system in SHR and WKY rats.
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Keywords
Supplement , Hypertensive