Ace And Actn3 Polymorphisms, Aerobic And Anaerobic Capacities, Bone And Muscular Performance In Malay Athletes And Non-Athletes

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dc.contributor.authorLi, Xiao
dc.date.accessioned2017-09-08T02:30:24Z
dc.date.available2017-09-08T02:30:24Z
dc.date.issued2016-04
dc.description.abstractThis study investigated the association between ACE gene I/D polymorphism and ACTN3 gene R577X polymorphism, aerobic and anaerobic capacities, bone and muscular performance in Malay athletes and non-athletes. A total of 132 participants were recruited in this study. Malay athletes (male athletes, n=33; female athletes, n=33) and non-athletes (male non-athletes, n=33; female non-athletes, n=33) participants were genotyped for ACE gene I/D polymorphism and ACTN3 gene R577X polymorphism by using PCR technique. Forced expiratory ratio (FER), maximal oxygen uptake (VO2max) and Wingate anaerobic power were measured. Meanwhile, the quantitative ultrasound measurements of bone speed of sound (SOS) and T-score of the participants’ dominant and non-dominant legs and arms were measured using a bone sonometer. Participants’ flexibility, handgrip strength, back and leg strength, leg explosive jump power were also measured. Muscular peak torque (PT, an indicator of muscular strength), peak torque per body weight (PT/BW) and average power (AVG.P) of the participants’ dominant and non-dominant knee and shoulder extension and flexion at 600.s-1, 1800.s-1 and 3000.s-1 were measured using BIODEX isokinetic dynamometer. The present study found that ACE II genotype was associated with higher VO2max in female and male athletes, and was associated higher muscular PT in female athletes. Meanwhile, ID genotype was associated with higher leg explosive jump power and lower fatigue index in female athletes, and was associated with higher muscular PT i.e. strength and power in male athletes. In female non-athletes, DD genotype was associated with better bone health status. This study also found that ACTN3 RR and RX genotypes were associated with higher flexibility in female athletes. Meanwhile, RR genotype was associated with leg explosive jump power in female athletes. In male athletes, RR genotype was associated with higher mean power. In both female and male athletes, RR genotype was associated with higher muscular PT and AVG.P, i.e. muscular strength and power. In female non-athletes, RR genotype was associated with better bone health status. In conclusion, the present findings obtained from this study can be used to guide the decisions of sports bodies and coaches in talent identification and selection of elite athletes in Malaysia, especially Malay ethnic group.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/4538
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectAnaerobic capacities, bone and muscular performanceen_US
dc.subjectin Malay athletes and non-athletes.en_US
dc.titleAce And Actn3 Polymorphisms, Aerobic And Anaerobic Capacities, Bone And Muscular Performance In Malay Athletes And Non-Athletesen_US
dc.typeThesisen_US
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