Anti-Cancer Effects Of Moringa Oleifera On Human Breast Adenocarcinoma Cell, MCF-7

Simple item page
dc.contributor.authorPoobalan, Kumararoobini
dc.date.accessioned2017-10-05T02:04:29Z
dc.date.available2017-10-05T02:04:29Z
dc.date.issued2017-06
dc.description.abstractIntroduction: Breast cancer is the leading factor of mortality worldwide, especially among women. According to World Health Organization (2015), breast cancer is the second most common cancer worldwide next to lung cancer and is known as the most common cancer among females. Moringa oleifera (M.oleifera) is a highly nutritious vegetable that serves various kind of therapeutic benefits especially as anti-cancer agent, thus widely used by researcher through many types of extraction and solvents to reveal its bioactive ingredients. Method: The current study carried out Ultrasound Assisted Sequential Extraction (UASE) using three solvents (Ethanol 99.7%. Ethanol 50% and Deionised Water) with ascending polarity. The resultant extracts were used to study their anti-cancer effects against human breast adenocarcinoma cell line, Mcf-7 and normal cell line, which is Human Umbilical Vein Endothelial Cell (HUVEC) with the aid of 3-(4, 5-dimethythiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. The IC50 value of the Ethanol 99.7%, Ethanol 50% and Deionised Water were 25, 200 and 180 μg/mL respectively. Ethanol 99.7% was found to be the best solvent for extracting as it gave the lowest IC50. Conclusion: M.oleifera is useful as a potential preventative and/or therapeutic agent in breast cancers either alone or as an adjunct to standard chemotherapeutic modalities.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/4811
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectAnti-cancer effects of moringa oleiferaen_US
dc.subjecton human breast adenocarcinoma cellen_US
dc.titleAnti-Cancer Effects Of Moringa Oleifera On Human Breast Adenocarcinoma Cell, MCF-7en_US
dc.typeThesisen_US
Files
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Institut Perubatan & Pergigian Termaju - Tesis