Dinuclear Silver(I)-N- Heterocyclic Carbene Complexes Based On Imidazolium Derivatives: Synthesis And Biological Activities
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Date
2018-07
Authors
Selvarajoo, Puvana Devi
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Publisher
Universiti Sains Malaysia
Abstract
This research describes the syntheses of two new series, non-functionalized series of four new precursor salts , namely 3,3' [(1,2 phenylenebis(methylene)] bis(1-cyclopentylimidazolium bis-hexaflourophosphate (1), 3,3' [(1,3 phenylenebis(methylene)] bis(1-cyclopentylimidazolium) bis-hexaflourophosphate (2), 3,3' [(1,4 phenylenebis(methylene)] bis(1-cyclopentylimidazolium) bis-hexaflourophosphate (3), 3,3' [(ethane-1,2-diyl)] bis(1-cyclopentylimidazolium) bis-hexaflourophosphate (4) and nitrile functionalized series of four new correspondence salt, namely 3,3' [(1,2 phenylenebis(methylene)] bis(4'-benzonitrilelimidazolium) bis-hexaflourophosphate (9), 3,3' [(1,3 phenylenebis(methylene)] bis(4'-benzonitrilelimidazolium) bis-hexaflourophosphate (10), 3,3' [(1,4 phenylenebis(methylene)] bis(4'-benzonitrilelimidazolium) bis-hexaflourophosphate (11) and 3,3' [(ethane-1,2-diyl)] bis(4'-benzonitrilelimidazolium) bis-hexaflourophosphate (12). Reaction of respective imidazolium salts with silver(I) oxide afforded the formation of two new series of silver(I)-NHC complexes, (5-8) and (13-16), respectively. The structures of all the compounds were confirmed by the elemental analysis data, (Fourier Transform Infrared spectroscopy, 1H and 13C NMR spectroscopy and CHN analysis). Selected molecular structure of compounds 3, 5, 7, and 10 were established by single crystal X-ray diffraction analysis. The antibacterial studies against the Gram-positive Staphyococcus aureus (S. aureus) (ATCC 12600) and Gram-negative Escherichia coli (E. coli) (ATCC 25922) of all sixteen compounds were carried out.
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Keywords
Dinuclear silver(i)-n- heterocyclic carbene complexes , based on imidazolium derivatives