SERUM ADIPONECTIN IN OVERWEIGHT AND NORMAL WEIGHT ADOLESCENTS AND ITS CORRELATION WITH INSULIN RESISTANCE AND LIPID PROFILE
Loading...
Date
2012
Authors
ANIZA, MOHAMMED JELANI
Journal Title
Journal ISSN
Volume Title
Publisher
Pusat Pengajian Sains Perubatan Universiti Sains Malaysia
Abstract
Introduction: Overweight has become a common heath problem in all over the world.
Adolescent age is a critical period in determining the adulthood obesity and its adverse
health consequences. Adiponectin, an adipocytokine which has a close association with
metaboli profiles of obesity-related diseases particularly insulin resistance and lipid
variables. Therefore this study was carried out to investigate those associations in
Malaysian adolescent population.
Objective: This study aimed to compare the levels of serum adiponectin between
overweight and normal weight adolescents and the correlation of adiponectin with insulin
resistance and lipid profile particularly HDL cholesterol as well as triglycerides in
overweight group and normal weight group.
Methods: A comparative cross sectional study was carried out on 58 overweight
adolescents and 60 normal weight adolescents attended National Training Service
Programme who fulfilled the inclusion and exclusion criteria. Serum adiponectin , fasting
serum insulin, fasting serum lipid profile and fasting plasma glucose were analyzed.
Insulin resistance was obtained by HOMA-IR formula.
Results: The mean adiponectin concentration was significantly lower in overweight
subjects compared to normal weight subjects (P = 0.005). The mean plasma glucose
concentration was higher in normal weight group than overweight group (P = 0.04). The
mean total cholesterol and mean HDL cholesterol concentrations were lower in overweight
subjects compared to normal weight subjects (P = 0.008, P < 0.001). There was no
significant correlation between adiponectin and HOMA-IR in overweight group and
normal weight group (P = 0.946, 0.224). Besides, no correlation was found between
adiponectin and TG in both groups (P = 0.55, 0.383). However there was a significant
correlation noted between adiponectin and HDL-cholesterol in overweight group (P =
0.004).
Conclusion: Our study supports that serum adiponectin has a role in the treatment obesity
and its related complications. This is evidenced by the lower level of this hormone in
overweight subjects and the significant positive correlation between adiponectin and HDLcholesterol
in overweight subjects.
Description
Keywords
Chemical Pathology