A Preliminary Study Of Risk Factors Of Breast Cancer And The Usefulness Of Breast MRI As An Addition To Mammography In Detecting Breast Cancer In High Risk Women
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Date
2016-01
Authors
Hashim, Nur Hashamimi
Journal Title
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Publisher
Universiti Sains Malaysia
Abstract
The risk factors of breast cancer among women, such as genetic, family history and lifestyle factors, can be divided into high, intermediate and average-risk. Screening of breast cancer which include mammography, can be done in promoting early breast cancer detection. Breast magnetic resonance imaging (MRI) has been recommended as a supplemental screening tool in high risk women. Therefore, the aim of this study was to identify the significant risk factor(s) of breast cancer among women and also to determine the usefulness of breast MRI as an addition to mammography in detection of breast cancer in high risk women. This retrospective cohort study design was conducted using patients’ data since 2007 until present. Data were taken from those who undergone mammography for screening or diagnostic purposes and diagnosed with breast cancer in Advanced Medical and Dental Institute, Universiti Sains Malaysia. Data from 289 subjects were successfully retrieved and analysed based on their risk factors of breast cancer. Meanwhile, data from 120 subjects who have undergone both mammography and breast MRI were also analysed. The final results showed that there were significant risk factors of breast cancer among the study population; family history of breast cancer (p=0.04), HER2 gene mutation (p= 0.006) and previous history of breast or ovarian cancer (p=<0.001). Breast MRI showed high sensitivity (90%) while mammography showed high specificity (80%) in detection of breast cancer. However, breast MRI was found to be non-significant as an adjunct tool to mammography in detecting breast cancer in high risk women (p value >0.05). In conclusion, this study showed that there were significant risk factors of breast cancer seen among women and there was no statistically significant usefulness of breast MRI as an addition imaging modality to mammography in detection of breast cancer in high risk women.
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Keywords
Risk factor of breast cancer , the usefulness of breast MRI