Preoperative and postoperative diffusion tensor imaging in patients with extra-axial lesions at the frontal or temporal regions of the brain and their correlations with neuropsychological outcomes
| dc.contributor.author | Hooi, Lim Liang | |
| dc.date.accessioned | 2018-09-23T04:08:45Z | |
| dc.date.available | 2018-09-23T04:08:45Z | |
| dc.date.issued | 2016 | |
| dc.description.abstract | The underlying changes in the neuronal connectivity adjacent to brain tumours cannot always be depicted by conventional MR imaging. The hypothesis of this study was that preoperative neuropsychological deficits are associated with impairment of diffusivity in association fibre bundles. Hence, we investigated the potential of combined diffusion tensor imaging (DTI) fibre tracking and fractional anisotropy (FA) values of the fibres to determine changes in association fibres and their correlation to neuropsychological scores. Our study consisted of eighteen patients with extra-axial brain tumours in areas adjacent to the frontal and temporal lobes. They were assessed pre-and postoperatively with DTI and neuropsychological assessments. MR examinations were performed on a 3T-scanner. FA values were calculated for the uncinate fasciculus, arcuate fasciculus, superior fronto-occipital fasciculus, inferior fronto-occipital fasciculus and corticospinal tracts ipsilateral and contralateral to the tumor. These values were compared with neuropsychological scores for language, memory and attention. The analysis revealed marked differences in pre- and post-excision of the tumor in both FA values and neuropsychological scores. Quantitative DTI was able to show significant differences in diffusivity of the association fibres before and after the surgery. The additional use of DTI-fibre integrity and neuropsychological tests may aid in prognostication and decision making prior to surgery. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/6611 | |
| dc.language.iso | en | en_US |
| dc.publisher | Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia | en_US |
| dc.subject | Diffusion magnetic resonance imaging | en_US |
| dc.title | Preoperative and postoperative diffusion tensor imaging in patients with extra-axial lesions at the frontal or temporal regions of the brain and their correlations with neuropsychological outcomes | en_US |
| dc.type | Thesis | en_US |
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