p53 EXPRESSION AS A PROGNOSTIC MARKER IN STAGE III GIANT CELL TUMOUR OF THE BONE

Thumbnail Image
Date
2012-05
Authors
NG, THONG PIN
Journal Title
Journal ISSN
Volume Title
Publisher
Pusat Pengajian Sains Perubatan Universiti Sains Malaysia
Abstract
Giant Cell Tumour of the bone is generally a benign neoplasm. However, it has a unique and an unpredictable behaviour where it tends to recur and metastasize to the lung. It seems to be more aggressive in Asian countries including Malaysia. To date, there are still many uncertainties in predicting the local recurrence and pulmonary metastasis of Giant Cell Tumour. The aim of this study is to determine the effectiveness of p53 expression as a prognostic marker in predicting risk of local recurrence and lung metastasis in GCT of bone. Fifty cases of Stage III GCT of bone presented to HUSM from January 1999 to December 2009 were reviewed and assessed for p53 expression using immunohistochemical staining. In this study, there were 29 male and 21 female patients. The mean age was 36.42 years ranging between 19 and 66 years old. Majority of the patients were Malays (82%) followed by Chinese (16%) and Indian (2%). The main site of tumour location was around the knees (48%) followed by 28% at the distal radius. Among the study subjects, 16% of cases had local recurrence and 24% presented with or eventually developed lung metastasis. Another 3% of cases presented with both local recurrence and lung metastases. The mean value of p53 expression was 37.68 with SD 28.33. The mean value of p53 expression was statistically significant in both groups comparing lung metastasis with non-lung metastasis group (p<0.001) and recurrence with non-recurrence group (p<0.005). The mean value of p5 expression in lung metastasis group (66.92) was slightly higher compared to local recurrence group (65.38). In conclusion, p53 expression may be considered as a reliable prognostic marker to predict the risk of local recurrence and lung metastasis in Giant Cell Tumour of the bone.
Description
Keywords
Orthopaedics
Citation
URI
http://hdl.handle.net/123456789/5166
Collections
Pusat Pengajian Sains Perubatan - Tesis