The Synthesis Of Group 10 Metals Schiff Base Complexes With Onn And Ons Groups: Characterization And Their Cytotoxicity And Antibacterial Activities
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Date
2018-02
Authors
Arafath, Md Azharul
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Twenty-one Schiff base ligands of salicyldehyde derivatives with heterocyclic amine, aniline and carbothioamide were synthesized. The ligands were coordinated to Group 10 transition metals Ni(II), Pd(II) and Pt(II). The synthesized compounds were characterized with physical parameters such as melting point and elemental analysis. These compounds were further characterized with spectroscopic techniques, i.e. FTIR, 1H NMR, 13C NMR, and UV-visible spectroscopy. The structure of most of the ligands were elucidated with single crystal X-ray diffraction analysis. The poly dentate ONS and ONN group containing ligands coordinated via imine nitrogen, phenolic oxygen and thiolate sulphur to form square planar complexes. The ligands form square planar and octahedral complexes with Ni(II). Square planar and tetra-palladate cluster complexes were obtained with Pd(II) with the ligands containing the ONS group. Square planar and macro complexes were obtained with Pt(II) and ONS group containing ligands. The biological activity was evaluated for their anticancer properties against three human breast cancer (MCF-7), cervical cancer (Hela), and colon cancer (HCT 116) cell lines. The complexes exhibited higher activity than ligands on all the cell types. In most of the series the Ni(II) complexes showed higher activity than Pd(II) and Pt(II). The L7-Ni showed highest activity against colorectal carcinoma with IC50 = .90 ± 0.40 μM among the synthesized compounds, whereas standard cisplatin shows IC50 =10.1 ± 1.00 μM. A few of the complexes showed very similar activity as standard existing drugs. Generally, the metal complexes exhibited higher activity than the ligands.
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Keywords
Schiff base ligands of salicyldehyde derivatives , with heterocyclic amine, aniline