Dna fragmentation in hela cells treated with Brucea javanica fruits extract

dc.contributor.author	Noor Hidayu, Pathni
dc.date.accessioned	2021-11-21T08:30:32Z
dc.date.available	2021-11-21T08:30:32Z
dc.date.issued	2008
dc.description.abstract	Fruits of Brucea javanica (B. javanica) have been used as traditional medicine in China as it has been shown to have antimalarial, antiplasmodial, antitumor or anticancer and antiamoebic. In this study, methanol extracts of B. javanica fruit (BJF) were treated on human cervical cancer cell (HeLa). Antiproliferative activity of BJF methanol extracts on HeLa cells showed ICso value of 13.34 J.l.g/ml. After that, TUNEL assay (Terminal Deoxynucleotide Transferase dUTP Nick End Labeling) was done to detect the apoptosis rate of BJF methanol extract on HeLa cells. The apoptosis rate for 24 h, 48 h and 72 h were 13.8%, 17.8% and 22.9% respectively. The percentage of apoptosis rate was time dependent. These results proposed that BJF methanol extracts exhibits antiproliferative effect on HeLa cells by inducing apoptosis. Therefore, it may be a potential candidate for antiproliferative agent for the treatment of human cervical cancer cells	en_US
dc.identifier.uri	http://hdl.handle.net/123456789/14387
dc.publisher	Pusat Pengajian Sains Perubatan Universiti Sains Malaysia	en_US
dc.subject	Fruits of Brucea javanica	en_US
dc.title	Dna fragmentation in hela cells treated with Brucea javanica fruits extract	en_US
dc.type	Other	en_US

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