Phytochemical And Bioactivity Studies Of Mimusops Elengi L
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Date
2011
Authors
Amir, Faheem
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Journal ISSN
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Publisher
Universiti Sains Malaysia
Abstract
Phytochemical investigation of the chloroform extracts of the leaves and bark of Mimusops elengi led to the isolation of spinasterol [15], ursolic acid [18] and 3β,6β,19α,23-tetrahydroxyurs-12-en-28-oic acid [67] from the leaves, as well as taraxerol [16] and spinasterol 3-O-β-D-glucopyranoside [39] from the bark. Compound [15] has previously been reported from the bark and seeds, compound [18] has been reported from the bark and mesocarp, and compound [39] has been reported from seeds of the plant. However, this is the first report of [15] and [18] from the leaves and [39] from the bark. Compound [67] has not, hitherto, been identified in M. elengi and the family Sapotaceae. Analysis of the volatile constituents of the flowers by capillary GC and GC/MS resulted in the identification of 50 compounds, the most abundant of which were 2-phenylethanol (29.8%), (E)-2-hexenal (11.8%) and benzyl alcohol (10.4%). The chloroform leaf and bark extracts, isolated compounds and flower volatile oil were tested for antibacterial activity using Gram-positive and Gram-negative bacteria, and anti-inflammatory activity using the cyclooxygenase assay. The majority of the samples tested indicated good activity against Staphylococcus aureus (9.7-78 μg/mL), while appreciable activity was observed against Gram-negative bacteria (78-156 μg/mL). Strong COX inhibition was observed for the leaf extract and [15], selective COX-2 inhibition was observed for [18] and [67], and selective COX-1 inhibition was observed for the bark extract, [39] and the flower oil. This study is the first report describing the anti-inflammatory potential of M. elengi. The results of this study support the Ayurvedic uses of the plant as crude antibacterial and anti-inflammatory agents.
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Keywords
Phytochemical investigation of the chloroform extracts , leaves and bark of Mimusops elengi led