Development Of Nano Formulation Composed Of Phospholipid-Encapsulated Standardized Extract Of Orthosiphon Stamineus To Enhance The Anti-Angiogenic Activity
| dc.contributor.author | Mansoureh, Nazari Vishkaei | |
| dc.date.accessioned | 2016-10-24T04:13:01Z | |
| dc.date.available | 2016-10-24T04:13:01Z | |
| dc.date.issued | 2016-01 | |
| dc.description.abstract | Orthosiphon stamineus (O.S) is a promising herb which has been shown to have potent antiangiogenic and antitumor activities. However, a high dose of O.S extract is required in order for it to be clinically effective. In this work, a nanotechnology based approach was adopted to enhance the antiangiogenic activity of O.S extract via phospholipidic carriers. The results of this study showed that a 1:1 ratio of O.S and phosphotidylcholine significantly improved the antiangiogenic activity of the extract. This formulation inhibited endothelial tube formation, and cell migration; and abrogated human colorectal cancer spheroids with significantly higher potency than pure unformulated O.S extract. The formulated particles had an average diameter of 29 nm. Although the formulation did not increase rosmarinic acid absorption specifically, HPLC data indicated the presence of rosmarinic-acid-phospholipids complexes. The data also shows increase in the solubility of sinensitin, eupatorin and 3’-hydroxy- 5, 6, 7, 4’-tetramethoxyflavone in an decreasing order of concentration. Moreover, the results of this study showes that rosmarinic acid was not the principal active component in O.S that conferes the antiangiogenic activity as O.S-phospholipids complexes shows potency which exceeded that of rosmarinic acid alone. The study presented a promising new formulation of O.S that may enhance its antitumor activity. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/2829 | |
| dc.language.iso | en | en_US |
| dc.publisher | Universiti Sains Malaysia | en_US |
| dc.subject | Nanotechnology | en_US |
| dc.title | Development Of Nano Formulation Composed Of Phospholipid-Encapsulated Standardized Extract Of Orthosiphon Stamineus To Enhance The Anti-Angiogenic Activity | en_US |
| dc.type | Thesis | en_US |
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