Synthesis, Characterization, Nucleoyltic, Antibacterial And Antipoliferative Properties Of Vanadium, Copper And Manganese Complexes
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Date
2011-07
Authors
Lim, Eng Khoon
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Series of vanadium carboxylato complexes, copper carboxylato complexes, manganese
carboxylato complexes and vanadium phenanthroline derivative complexes have been
synthesized and characterized. The details of all the complexes are tabulated in Table 2.2
(page 37). The complexes have been characterized by X-ray crystallography, elemental
analysis, FT-IR, UV–Vis spectroscopy and cyclic voltammetry. In electrochemistry
studies, vanadium carboxylato complexes show redox active by displaying a quasireversible
redox couple corresponding to VV/VIV redox process while copper
carboxylato complexes show redox active by displaying two quasi-reversible redox
couples corresponding to CuIICuII/CuIICuI and CuIICuI/CuICuI redox processes and
manganese carboxylato complexes show redox active by displaying a quasi-reversible
redox couple corresponding to MnII/MnIII redox process. In nucleolytic studies, all the
complexes can induce oxidative DNA cleavage but in different manner. The copper
carboxylato complexes and manganese carboxylato complexes can induce DNA
cleavage in the presence of H2O2. Meanwhile for vanadium carboxylato complexes,
vanadium(V) carboxylato complexes require H2O2 to induce DNA cleavage while
vanadium(IV) carboxylato complexes do not require H2O2 to induce DNA cleavage. As
for vanadium phenanthroline derivative complexes, they can induce DNA cleavage in
the presence and in the absence of H2O2. However, the DNA cleavage activity of the
vanadium phenanthroline derivative complexes is greatly enhanced in the presence of
H2O2. Reactive oxygen species (ROS) scavengers have also been used to ascertain the
reactive species responsible for DNA cleavage.
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Keywords
Antipoliferative properties of vanadium , copper and manganese complexes