Properties Of Bioactive Glass Reinforced Polyurethane Scaffold By Solvent Casting/Particulate Leaching Method
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Date
2019-08-01
Authors
Suhaimin, Intan Syazana
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
The properties of polyurethane-Bioglass® (PU-BG) scaffolds have been
optimized using solvent casting/particulate leaching (SC/PL) method. Processing
parameters such as polymer solution concentration (15, 16, 17, 18 and 19 wt/vol%),
leaching agent concentration with ratio between PU and NaCl (1:3, 1:4, 1:5, 1:6 and
1:7), leaching agent composition by percentage of NaCl/NaHCO3 (100/0, 85/15,
75/25, 65/35, 55/45 and 45/55) and percentage of Bioglass® (0, 10, 20, 30 40 and 50 wt%) were investigated to obtain the desired properties of PU-BG scaffolds. The
scaffolds were characterized using field emission scanning electron microscopic
(FESEM), porosity test, fourier transform infrared (FTIR), compression test,
inductively coupled plasma (ICP) and degradation test. The optimum parameters to
fabricate PU-BG scaffold were found to be 19 wt/vol % of polymer solution
concentration, 1:6 ratio (PU: NaCl) of leaching agent concentration and leaching agent
composition between 65% NaCl and 35% NaHCO3. The optimization process was
able to fabricate the composite scaffold with the thickness more than 20 mm without
the formation of undesirable dense layer. Besides, the PU-BG scaffolds were observed
with well interconnected porous structure with the pore size spanning over a wide
range and adequate porosity for the bone tissue application. The results demonstrated
that, the increased in percentage of Bioglass® from 0 wt% to 50 wt% was found to
improve the compressive strength as well as induced and accelerated an apatite
formation during in-vitro test.