A pilot study on red cell immunization in multiply transfused thalassaemic patients
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Date
2005-05
Authors
Noor, Noor Haslina Mohd
Journal Title
Journal ISSN
Volume Title
Publisher
Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
Abstract
BACKGROUND: The development of red blood cell (RBC) isoitnniunization with
alloantibodies and autoantibodies cotnplicate transfusion therapy in multiply transfused
thalassaemia patients. Thus, frequency, causes and prevention of these phenomena were
studied among these patients.
STUDY DESIGN AND METHODS: Clinical and serological data of 58 Malay multiply
transfused thalassaemia patients who seek their treatment in 1-Iospital University Sains
Malaysia were collected and analyzed prospectively. Blood samples were subjected to
standard blood bank procedure for screening of antibodies and subsequent antibodies
identification. All patients in our hospital received blood n1atched for only ABO and Rh
(D) antigens.
RESULTS: There were 46 (79.3%) patients with Hb E/f3 thalassactnia~ 8 (13.8%) f3
thalassaemia major, 3 (5.2%) J-Ib 1-1 Constant Spring and I (1.7%) Hb 1-1 disease. Overall,
8.6% of the patients had alJoantibodies and 1. 7% had autoantibodies. The alloantibodies
identified were anti-E, anti-c, anti-K, anti-Jka, anti-N and anti-S.
CONCLUSION: The transfusion of tnatched blood is essential for chronically nlultitransfused
patients in order to avoid alloimmunisation. Considering high frequency of anti
E in our hospital, it is advisable to genotype patients and n1atch the red cell unit for E
antigens in multiply transfused thalassaemia patients.
Description
Keywords
Thalassaemia