Colorectal carcinoma in Hospital Kuala Terengganu from 1987 to 1999
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Date
2002
Authors
Ramasamy, Umasangar
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Colorectal carcinoma is one of the most common malignant
neoplasm in this country. Its incidence is rising. New development in genetic studies has brought better understanding of colorectal carcinoma. Newer treatment option has increased survival and quality of life.
However the impact of this development has not been fully
utilized especially in the rural areas in this country.
To study the epidemiology of colorectal carcinoma in the
Kuala Terengganu Hospital and the state ofTerengganu. To determine the clinical presentation of colorectal carcinoma in this hospital and to evaluate the mode of investigation and treatment received by the patients with colorectal carcinoma . The primary objective is to assess the
treatment outcome in tenns of recurrence and survival .
Between 19 87 to 1999, 90 patients were treated in Hospital Kuala Terengganu for colorectal carcinoma. The sex, age , duration of symptom, the main and subsequent presenting problems, the type of special investigation and the location of the tumour were determined from
patients record. Type of surgery, method of resection and presence of metastases were noted at the time of surgery . Specimens were sent to the pathologist for assessment of the tumour grade.
Survival duration were obtained from the patients record . 2 year survival rate was assessed and factors affecting survival were determined using nonparametric statistical analysis .
There was almost equal sex distribution among the patients. 53% of the patients were more then 60 years and young colorectal carcinoma
consist of6%. Median duration of symptom was 4.3 months. 43.3% of the patients presented with intestinal obstruction and a almost equal number of them underwent emergency surgery. 68.7% of the patients were in Duke's C and D at presentation . At the time of presentation 24.4 % already had liver metastases . 30 day mortality and morbidity was 2.2% and 11.1% respectively . Overall swvival was 37.8%. Statistically Duke's staging, stage of metastases, initial clinical presentation , type of operation and use of adjuvant therapy significantly influences( p <0.05) the 2 year survival in this study.
In this study, late presentation of colorectal carcinoma was common. Duke's staging, initial clinical presentation, type of opemtion and the use of chemotherapy influences survival . A better follow up of colorectal carcinoma patient is needed.
Description
Keywords
Colorectal carcinoma