The Effects Of Channa Striatus Extract Administration On Wound Healing Markers (Il-6, Mmp-9 And Vegf) In Post Lower Segment Caesarean Section (LSCS) Women
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Date
2016-12
Authors
Zainan, Ahmad Ezam
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Journal ISSN
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Publisher
Universiti Sains Malaysia
Abstract
Channa striatus (ikan haruan) is widely consumed in Malaysia to promote wound healing. For centuries, C.striatus has been proposed to have anti-inflammatory, anti-oxidant and anti-nociceptive properties for better healing of the wound. Wound healing is a dynamic process that involves four disticnt yet an overlapping phases; haemostasis, inflammation, proliferation and tissue remodeling. It starts immediately after injury and proceeds with a complicated but well-organized interaction among various types of tissues and cells. During wound healing process, leukocytes, macrophages and endothelial cell release various growth factors and cytokines such as interleukin 6 (IL-6), matrix metalloproteinase 9 (MMP-9) and vascular endothelial growth factor (VEGF). IL-6 regulates leukocytes recruitment to the inflammatory sites. MMP-9 involves in removal of damaged extracellular matrix, migration of epidermal cells and tissue remodelling. VEGF stimulates the new blood vessels formation through a process called angiogenesis. This study was done to compare the level and trends of IL-6, MMP-9 and VEGF in patients receiving C.striatus extract and placebo (maltodextrin) during wound healing of post lower segment caesarean section (LSCS). This was a randomized; double blinded, placebo-controlled study conducted in Hospital USM and Hospital Raja Perempuan Zainab II. The treatment group was administered orally with 500 mg of freeze dried C.striatus extract daily while the placebo group with 500 mg of maltodextrin daily for 6 weeks. Venous blood samples were taken from each subject post-operatively at
day 1, day 3, week 2, week 4 and week 6 and analysed for healing markers (IL-6, MMP-9 VEGF) and safety profile test (FBC, BUSE, Creatinine, ALT and AST). Statistical analysis were done using SPSS Version 22. A total of 73 patients were studied, 39 patients consumed C.striatus and 34 consumed maltodextrin. From this study, the level of wound healing markers ( IL-6, MMP-9 and VEGF) was higher in C.striatus extract group compared to placebo. Comparison between C.striatus extract group and placebo (maltodextrin) group for IL-6 and MMP-9 were significantly different at week 4 (p < 0.001, p < 0.05) and week 6 (p < 0.001, p < 0.05) respectively whereas VEGF show significant different at day 1 (p < 0.05), day 3 (p < 0.05), week 4 ( p < 0.05 ) and week 6 (p < 0.001). In contrast, comparison between groups shows no significant different for IL-6 and MMP-9 at day 1 (p = 0.475, p = 0.104), day 3(p = 0.131, p = 0.315) and week 2 (p = 0.052, p = 0.397) respectively, except for VEGF which not significant at week 2 (p = 0.738).This study also shows some trends in conjunction with healing phase and shows that the indication of C.striatus extract was involved in enhancing the wound healing process.
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Keywords
Channa striatus (ikan haruan) is widely consumed , to promote wound healing.