Study on vitamin D status and determination of optimum vitamin D level based on bone turnover markers in Kota Bharu, Kelantan
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Date
2018
Authors
Muda, Noor Bayani Che
Journal Title
Journal ISSN
Volume Title
Publisher
Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
Abstract
Background: There is no optilnmn level or threshold that has been clearly established
to define whether there is adequate store of vitamin D in the body for general bone
health. Therefore, our study is to determine the optimum level of vitamin D for
maintenance of healthy skeleton based on bone remodelling process.
Methods: This was a cross sectional study involving healthy adult population in Kota
Bharu, Malaysia, aged 18-50 years. We measured serwn 25(0H)D, serum parathyroid
hormone (PTH), serum C-terminal telopeptide of type 1 collagen ( CTX) and
Procollagen 1 Intact N-Terminal (P1NP) in 120 healthy adult from 6 sub districts that
had been selected by multi stage sampling ( 64 males, 56 females).
Results: The mean of vitamin Din this study was 23.50 (±8.74) nmol/L and there was
significant difference of vitamin D betvveen gender (26.81±8.3 nmol/L and 19.72±7.68
nmol/L males and females respectively), p value < 0.001. More than 50% of female
subjects had vitamin D less than 20 nmol/L, while only 20.3% of male subjects had
vitamin D below 20 nmol/L. Based on LOESS plot, the bone turnover markers showed
plateau result at vitamin D level of 3 5 nmoi!L for CTX and 20 nmoi/L for p 1 NP. Then,
at vitamin D level of 20 nmol/L there is a step decrease of PTH level.
Conclusion: The mean of vitamin D among general healthy population in Kota Bharu
was 23.50nmoi/L. Based on inspection of LOESS plot for CTX, PlNP and PTH versusvitamin D level, we concluded that vitamin D level between 20 nmol/L to 35 nmol/L is
considered sufficient to maintain healthy skeleton.
Description
Keywords
Vitamin D , Standards