Use Of Fresh Frozen Plasma At Hospital Selayang: A Retrospective Study
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Date
2017
Authors
Ridzuan, Diyana Mazuin
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Background. FFP transfusion has increased in demand over the years and the global trending of high FFP usage can be seen in many countries. It has been used since 1920’s and if appropriately used, it can improve the quality of life. However FFP transfusion is not without risk. It may cause adverse transfusion reaction such as allergic reaction, TRALI, TACO and transfusion transmitted infections. Thus this study was conducted to assess the indication of FFP transfusion against the guideline available.
Objective. To assess the appropriateness of the use of fresh frozen plasma at Hospital Selayang against the National Guideline for the rationale use of blood and blood products and international guideline by College of American Pathologist.
Method. A retrospective study among adult patients receiving fresh frozen plasma from 1 January 2016 until 31 December 2016 by reviewing total hospital information system (THIS), blood order and transfusion reaction forms. The appropriateness of requests was assessed against existing guidelines. The percentage of indicated diagnosis (appropriate) and not indicated diagnosis (inappropriate) FFP transfusions were obtained.
Result. Total of 373 patients receiving FFP were included in this study. About 73.2% of the patients were given FFP with indicated diagnosis and is considered appropriate while 26.8% was inappropriate. HPB and Orthopaedic are the most departments to transfused FFP inappropriately. Those with normal INR were 3.22 times higher odds of being inappropriate for FFP transfusion compared to those with
prolong INR readings. Total of 4.3% patients developed transfusion reaction mainly mild allergic and febrile non hemolytic reaction (FNHR).
Conclusion. Inappropriate transfusion exposes patient to unnecessary adverse event and thus should be monitored and prevented by all means. The findings of this study are beneficial to justify the role of clinicians in making the right decision in transfusion practices.
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Keywords
The appropriateness of the use , of fresh frozen plasma.