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Neuroprotective Effects Of Diterpenoids-Enriched Fraction Of Andrographis Paniculata And Andrographolide In Ischaemia-Induced Neuronal Death And Cognitive Impairment: In Vitro And In Vivo Models

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Date
2025-08
Authors
Che Lamin, Roz Azinur
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Abstract
Andrographis paniculata (Burm.f.) Wall. ex Nees, known as “hempedu bumi”, has been studied for its cognitive-enhancing and neuroprotective effects. However, the study on the potential of A. paniculata diterpenoids-enriched fraction against learning and memory impairment is limited, particularly in vascular-pathology-related dementia. Thus, this study aimed to enhance the methanolic extract of A. paniculata via the enrichment of diterpenoids through a fractionation process and evaluate its cognitive-enhancing and neuroprotective effects along with andrographolide, the major diterpenoid of A. paniculata, using in vitro and in vivo models.
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Neuroprotective Effects Of Diterpenoids-Enriched Fraction Of Andrographis Paniculata And Andrographolide , Ischaemia-Induced Neuronal Death And Cognitive Impairment , In Vitro And In Vivo Models
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https://erepo.usm.my/handle/123456789/24859
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Pusat Pengajian Sains Farmasi - Tesis