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Neuroprotective Effects Of Diterpenoids-Enriched Fraction Of Andrographis Paniculata And Andrographolide In Ischaemia-Induced Neuronal Death And Cognitive Impairment: In Vitro And In Vivo Models

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dc.contributor.authorChe Lamin, Roz Azinur
dc.date.accessioned2026-08-19T03:21:25Z
dc.date.available2026-08-19T03:21:25Z
dc.date.issued2025-08
dc.description.abstractAndrographis paniculata (Burm.f.) Wall. ex Nees, known as “hempedu bumi”, has been studied for its cognitive-enhancing and neuroprotective effects. However, the study on the potential of A. paniculata diterpenoids-enriched fraction against learning and memory impairment is limited, particularly in vascular-pathology-related dementia. Thus, this study aimed to enhance the methanolic extract of A. paniculata via the enrichment of diterpenoids through a fractionation process and evaluate its cognitive-enhancing and neuroprotective effects along with andrographolide, the major diterpenoid of A. paniculata, using in vitro and in vivo models.
dc.identifier.urihttps://erepo.usm.my/handle/123456789/24859
dc.language.isoen
dc.subjectNeuroprotective Effects Of Diterpenoids-Enriched Fraction Of Andrographis Paniculata And Andrographolide
dc.subjectIschaemia-Induced Neuronal Death And Cognitive Impairment
dc.subjectIn Vitro And In Vivo Models
dc.titleNeuroprotective Effects Of Diterpenoids-Enriched Fraction Of Andrographis Paniculata And Andrographolide In Ischaemia-Induced Neuronal Death And Cognitive Impairment: In Vitro And In Vivo Models
dc.typeResource Types::text::thesis::doctoral thesis
dspace.entity.typePublication
oairecerif.author.affiliationUniversiti Sains Malaysia
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