Publication: Formulation And Evaluation Of Liquid Crystalline Nanostructures For The Pulmonary Delivery Of Docetaxel
| dc.contributor.author | Yousif, Ibrahim M. Abdulbaqi Almalla | |
| dc.date.accessioned | 2026-06-19T03:02:43Z | |
| dc.date.available | 2026-06-19T03:02:43Z | |
| dc.date.issued | 2025-05 | |
| dc.description.abstract | Lung cancer is the leading cause of cancer-related deaths worldwide. Docetaxel (dtx) is a widely used chemotherapeutic agent; however, its poor solubility, low bioavailability, and high systemic toxicity limit its therapeutic efficacy. Conventional intravenous formulations utilise ethanol and surfactants such as polysorbate 80 (tween 80®), which cause severe adverse effects, including nephrotoxicity and hypersensitivity. This underscores the need for targeted drug delivery to enhance dtx efficacy while minimising systemic toxicity. Pulmonary delivery via lipid-based nanoparticles, particularly liquid crystalline nanostructures (lcns), presents a non-invasive and efficient approach with improved patient compliance. This study aimed to develop and characterise inhalable dtx-loaded lcns for pulmonary delivery, optimising anticancer efficacy while potentially reducing adverse effects. Lcns were prepared via extrusion, ensuring minimal dispersed phase loss and structural integrity. Small-angle x-ray scattering (saxs) confirmed cubic internal nanostructures, validating extrusion as a scalable fabrication method. A series of four full factorial experiments yielded 40 formulations, of which 11 met the selection criteria of highest lipid content, smallest particle size (ps), and a polydispersity index (pdi) < 0.25. Dtx was loaded at 2, 5, and 10 mg/ml, with 5 mg/ml identified as optimal. | |
| dc.identifier.uri | https://erepo.usm.my/handle/123456789/24418 | |
| dc.language.iso | en | |
| dc.subject | Formulation Evaluation Liquid Crystalline Nanostructures Pulmonary | |
| dc.title | Formulation And Evaluation Of Liquid Crystalline Nanostructures For The Pulmonary Delivery Of Docetaxel | |
| dc.type | Resource Types::text::thesis::doctoral thesis | |
| dspace.entity.type | Publication | |
| oairecerif.author.affiliation | Universiti Sains Malaysia |