Publication: Maternal And Neonatal Characteristics In Fetal/neonatal Alloimmune Thrombocytopenia In National Blood Centre
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Date
2021-05
Authors
Nalliappan, Parameswari
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Abstract
Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is an uncommon condition due to maternal alloimmunization of fetal platelet leading to thrombocytopenia in fetal and neonate. The aim of this study was to determine the incidence of FNAIT in Malaysia and the associated maternal and neonatal factors. Retrospective data analysis of matched, case control study (39 FNAIT cases and 39 randomly selected controls) from the year 2011 to 2019 at National Blood Centre, Malaysia. Maternal and neonatal characteristics were compared with controls. The incidence of FNAIT in Malaysia was 0.85 per 100 000 live births.Common anti-Human Platelet Antigen (-HPA) identified in this study were Anti-HPA-5b, Anti-HPA-3a and Anti-HPA-5a. Fifty-eight (58%) (p=0.012) of mothers were younger than 35 years old, of Malay ethnicity and multiparous. Malay mothers were 4.8 times more likely to develop FNAIT as compared to non-Malay. Neonatal onset of presentation, platelet count and blood group were not significantly different than in control group. The most significant factor associated with FNAIT was neonatal presentation. Symptomatic neonates were more likely to develop FNAIT. Incidence of FNAIT among Malaysians was lower than reported in the literature. Malay mothers and neonates presenting with symptoms are more likely to have FNAIT.
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Keywords
neonatal alloimmune thrombocytopenia , incidence , human platelet antigen , Nalliappan , Parameswari