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Maternal And Neonatal Characteristics In Fetal/neonatal Alloimmune Thrombocytopenia In National Blood Centre

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dc.contributor.authorNalliappan, Parameswari
dc.date.accessioned2026-04-16T07:46:05Z
dc.date.available2026-04-16T07:46:05Z
dc.date.issued2021-05
dc.description.abstractFetal/neonatal alloimmune thrombocytopenia (FNAIT) is an uncommon condition due to maternal alloimmunization of fetal platelet leading to thrombocytopenia in fetal and neonate. The aim of this study was to determine the incidence of FNAIT in Malaysia and the associated maternal and neonatal factors. Retrospective data analysis of matched, case control study (39 FNAIT cases and 39 randomly selected controls) from the year 2011 to 2019 at National Blood Centre, Malaysia. Maternal and neonatal characteristics were compared with controls. The incidence of FNAIT in Malaysia was 0.85 per 100 000 live births.Common anti-Human Platelet Antigen (-HPA) identified in this study were Anti-HPA-5b, Anti-HPA-3a and Anti-HPA-5a. Fifty-eight (58%) (p=0.012) of mothers were younger than 35 years old, of Malay ethnicity and multiparous. Malay mothers were 4.8 times more likely to develop FNAIT as compared to non-Malay. Neonatal onset of presentation, platelet count and blood group were not significantly different than in control group. The most significant factor associated with FNAIT was neonatal presentation. Symptomatic neonates were more likely to develop FNAIT. Incidence of FNAIT among Malaysians was lower than reported in the literature. Malay mothers and neonates presenting with symptoms are more likely to have FNAIT.
dc.identifier.urihttps://erepo.usm.my/handle/123456789/23948
dc.language.isoen
dc.subjectneonatal alloimmune thrombocytopenia
dc.subjectincidence
dc.subjecthuman platelet antigen
dc.subjectNalliappan
dc.subjectParameswari
dc.titleMaternal And Neonatal Characteristics In Fetal/neonatal Alloimmune Thrombocytopenia In National Blood Centre
dc.typeResource Types::text::thesis::master thesis
dspace.entity.typePublication
oairecerif.author.affiliationUniversiti Sains Malaysia
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