Publication: Computational Design And Investigation Of New Benzophenones And Benzophenone Imines Inhibitors For Breast Cancer
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Date
2018-10
Authors
Shtaiwi, Amneh Mohammad
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Abstract
The computational methods of protein-ligand interactions are core components in drug design and modem drug discovery. This study attempted to design and investigate the interactions of new human estrogen receptor (hERa) inhibitors to treat
breast cancer cells using molecular modeling approach. The proposed inhibitors were designed by replacing the triarylethylene estrogenic scaffold found in the synthetic inhibitor 4-hydroxytamoxifen (4-0HT) with triarylimine Schiff bases.
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Keywords
Benzophenone , Imines