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Therapeutic effects of bunga kantan (Etlingera elatior) flower aqueous extract on streptozotocin-induced diabetic sprague-dawley rats.

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dc.contributor.authorNawi, Afifah
dc.date.accessioned2025-03-16T03:59:39Z
dc.date.available2025-03-16T03:59:39Z
dc.date.issued2017
dc.description.abstractDiabetes mellitus is a chronic metabolic disorder that becomes a burden on global health. The warning sign of diabetes include polyuria, polydipsia, unexplained weight loss and blurry vision. Uncontrolled diabetes leads to long-term complication including diabetic nephropathy and hypertension. Modem oral hypoglycemia drugs are costly and have side effects. Thus, people are seeking for herb-sources complementary therapies which are cost-effective. The flower of Etlingera elatior or ‘Bunga Kantan’ has been used traditionally to lower blood sugar in diabetic sufferer. In this study, bunga kantan aqueous extract (BKAE) was evaluated for its anti-diabetic effect on diabetic rats model. Diabetes was induced into Sprague-Dawley rats by single doses of intraperitoneal STZ (60mg/kg). Twenty-four (24) rats equally were divided into 4 groups. Group 1; normal group, Group 2; untreated diabetic group, Group 3; 300mg/kg BKAE treated-group and Group 4; 250mg/kg metformin treated-group. The effects of BKAE on blood glucose level, body weight, kidney function and blood pressure were evaluated for 6 weeks treatment (sub-acute in vivo study). Blood glucose level and body weight were measured weekly, while blood pressure only measured at the end of study. Histology study of kidney (hematoxylin and eosin staining (H&E)), phytochemical screening and toxicity study of BKAE also investigate in this study. Six-weeks treatment of oral BKAE significantly reduced blood glucose level in diabetic rat, comparable to metformin. Body weight of BKAE treated-rat also increased. BKAE significantly reduced blood pressure and improved the kidney function. Histology BKAE-treated kidney resembles normal kidney comparable to metformin. Flavonoids, tannins, quinines, terpenoids and coumarin were the chemical constituents screened in BKAE. Lethal dose for BKAE was aboved 5000 mg/kg of BKAE. Overall, this study has shown that bunga kantan has hypoglycaemic effect and improved the secondary complications from diabetes.
dc.identifier.urihttps://erepo.usm.my/handle/123456789/21316
dc.language.isoen
dc.subjectEtlingera elatior
dc.subjectbunga kantan
dc.subjectdiabetes
dc.subjectstreptozotocin
dc.subjectsubacute in vivo
dc.subjecthistology
dc.titleTherapeutic effects of bunga kantan (Etlingera elatior) flower aqueous extract on streptozotocin-induced diabetic sprague-dawley rats.
dc.typeResource Types::text::report::research report
dspace.entity.typePublication
oairecerif.author.affiliationUniversiti Sains Malaysia.
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