Publication:
Design, Synthesis, Biological Evaluation, And Molecular Docking Studies Of Ortho-Carboxamido Stilbenes As Anti-Diabetic And Anti-Proliferative Agents

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Date
2022-09
Authors
Norhadi Bin Mohamad
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Research Projects
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Abstract
A total of eleven ortho-carboxamido stilbenes (50a-50k) in 63-83 % yield have been synthesized using our modified Heck coupling method, and characterized using FT-IR, NMR, and HRMS. The research started with the Wittig reaction of 3,5-dimethoxybenzaldehyde (45) and methyltriphenylphosphonium iodide to form 3,5-dimethoxystyrene (46) followed by the Heck reaction with amide derivatives (49) under basic conditions to provide the corresponding (E)-stilbene derivatives (50a-50k). Five ortho-carboxamido stilbenes (50a-50e) were subjected to anti-diabetic studies on α-amylase and α-glucosidase enzymes.
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Design , Synthesis , Biological Evaluation , And Molecular Docking Studies , Ortho-Carboxamido Stilbenes As Anti-Diabetic , Anti-Proliferative Agents
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https://erepo.usm.my/handle/123456789/17965
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Pusat Pengajian Sains Kimia - Tesis