Publication:
Design, Synthesis, Biological Evaluation, And Molecular Docking Studies Of Ortho-Carboxamido Stilbenes As Anti-Diabetic And Anti-Proliferative Agents

Simple item page
dc.contributor.authorNorhadi Bin Mohamad
dc.date.accessioned2024-01-02T03:20:09Z
dc.date.available2024-01-02T03:20:09Z
dc.date.issued2022-09
dc.description.abstractA total of eleven ortho-carboxamido stilbenes (50a-50k) in 63-83 % yield have been synthesized using our modified Heck coupling method, and characterized using FT-IR, NMR, and HRMS. The research started with the Wittig reaction of 3,5-dimethoxybenzaldehyde (45) and methyltriphenylphosphonium iodide to form 3,5-dimethoxystyrene (46) followed by the Heck reaction with amide derivatives (49) under basic conditions to provide the corresponding (E)-stilbene derivatives (50a-50k). Five ortho-carboxamido stilbenes (50a-50e) were subjected to anti-diabetic studies on α-amylase and α-glucosidase enzymes.
dc.identifier.urihttps://erepo.usm.my/handle/123456789/17965
dc.subjectDesign
dc.subjectSynthesis
dc.subjectBiological Evaluation
dc.subjectAnd Molecular Docking Studies
dc.subjectOrtho-Carboxamido Stilbenes As Anti-Diabetic
dc.subjectAnti-Proliferative Agents
dc.titleDesign, Synthesis, Biological Evaluation, And Molecular Docking Studies Of Ortho-Carboxamido Stilbenes As Anti-Diabetic And Anti-Proliferative Agents
dc.typeResource Types::text::thesis::master thesis
dspace.entity.typePublication
oairecerif.author.affiliationUniversiti Sains Malaysia
Files
Collections
Pusat Pengajian Sains Kimia - Tesis