Publication: A randomized controlled trial comparing two doses of caffeine for apnoea in prematurity
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Date
2021
Authors
Kori, Anis Munirah Mohd
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Abstract
Caffeine is the most used methyl xanthine for the prevention of apnoea in prematurity, but its ideal dose was uncertain. This study compared two doses of caffeine for prevention of apnoea in prematurity. A clinical trial was conducted on 78 preterm infants ≤32 weeks in NICU at tertiary center hospital. They were randomly allocated to receive the intervention (loading 40 mg/kg/day and maintenance of 20 mg/kg/day) or the control (loading 20 mg/kg/day and maintenance of 10 mg/kg/day) dose of caffeine. The primary outcome of the study was the frequency and total days of apnoea per duration of treatment for both groups. The frequency of apnoea range from zero to fourteen in the intervention and zero to twelve in control group. There was no statistically significant different between the groups with p value 0.839. The number of days of apnoea was also similar between both groups with p value 0.928. There was also no significant difference of adverse events between both regimens. This study did not support the use of higher dose caffeine as a prevention for apnoea in prematurity
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Keywords
apnoea , prematurity