Publication: Anti-angiogenic Properties Of Nanoparticles: A Systematic Review
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Date
2018
Authors
Salem Brhaish, Ali Saeed
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Abstract
Introduction: Angiogenesis develops new blood vessels from the old ones, and this process is controlled by balancing the angiogenic and anti-angiogenic factors. The domination of angiogenic leads to pathological angiogenesis that causes diseases, such as diabetic retinopathy and cancer. Anti-angiogenesis therapy targets angiogenesis to treat these diseases. Hence, nanoparticles appear to be one of the most promising agents that offer efficacy in therapy. The objective of this research is to review systematically studies that have probed into the effect of nanoparticles on angiogenesis. Methodology: The literature was searched electronically (PubMed, Science Direct, Google Scholar, Medline, Scopus, and Springer) to identify as many relevant articles as possible for the topic at hand, which is the effect of nanoparticles on angiogenic. The inclusion criteria, such as articles published in the English language during the period from January 2008 until January 2018, were strictly adhered to. The Medical Subject Heading (MeSH) (nanoparticles) and anti-angiogenesis or angiogenesis were used to extract articles from PubMed and Medline, while search terms or keywords of the title had been applied to retrieve more journals and articles from other databases. Additionally, references that were cited in the initial search were sought to identify more potential articles. Next, articles that did not meet the inclusion criteria and those duplicate were discarded. Results: Out of the 218 articles obtained from the literature search, only 22 seemed to conform to the inclusion criteria. The spherical shape is the most common shape employed to investigate the role of nanoparticles in angiogenesis therapy. The size of nanoparticles appears to play a crucial role for efficacy on angiogenesis, in which 20 nm emerged as the preferred size. Gold nanoparticle exhibit the most promising type as an anti-angiogenesis agent. The nanoparticles were active for both in vitro and in vivo models. The biosynthesis of nanoparticles is safer than chemical synthesis. The toxicity was adjustable based on the dosages applied. Conclusion: Nanoparticles are a promising treatment for angiogenesis-related diseases. Nanoparticles inhibit angiogenesis in different pathways. Size and shape play a role in the anti-angiogenesis effects of nanoparticles. Gold nanoparticle exhibit higher anti-angiogenesis properties.
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Keywords
Nanoparticles , angiogenesis , anti-angiogenesis , size , toxicity