Effects Of Cross-Fostering And Melatonin Supplementation On The Development Of Hypertension And Renal Antioxidant/Oxidant System In Spontaneously Hypertensive Rats
Loading...
Date
2011-08
Authors
Lee, Siew Keah
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Various interventions in early life in SHR have been attempted to reprogramme
the raised blood pressure profile in SHR but with limited and only
transient benefits. This study examined the effects of either cross-fostering or
antenatal and postnatal melatonin supplementation alone or in combination on the
development of hypertension and renal antioxidant/oxidant system in SHR and WKY
rats. In the first stage of the study, blood pressure and antioxidant profiles in SHR
and WKY rats were measured. After this the effect of cross-fostering was examined
where one-day-old SHR and WKY pups were cross-fostered to the dam of the
opposite strain and the male offspring were then raised up to 16 weeks of age. In the
next stage, melatonin (10mg/kg body weight/day) was supplemented via drinking
water to pregnant SHR/WKY from pregnancy day-1 and up to postpartum day-21,
and then continued to be given to some of the weaned male offspring up to 16 weeks
of age. In the following stage, one-day-old offspring of melatonin supplemented
SHR and WKY dams were cross-fostered and after weaning some of these crossfostered
male offspring continued to receive melatonin via drinking water up to 16
weeks of age. Systolic blood pressure (SBP) of all the male offspring was recorded
at the age of 4, 6, 8, 12 and 16 weeks, and the kidneys were collected for the
estimation of antioxidant/oxidant status at the end of each age category.
Description
Keywords
Cross-Fostering And Melatonin Supplementation , Hypertension