Effects Of Cross-Fostering And Melatonin Supplementation On The Development Of Hypertension And Renal Antioxidant/Oxidant System In Spontaneously Hypertensive Rats

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dc.contributor.authorLee, Siew Keah
dc.date.accessioned2019-10-04T02:41:47Z
dc.date.available2019-10-04T02:41:47Z
dc.date.issued2011-08
dc.description.abstractVarious interventions in early life in SHR have been attempted to reprogramme the raised blood pressure profile in SHR but with limited and only transient benefits. This study examined the effects of either cross-fostering or antenatal and postnatal melatonin supplementation alone or in combination on the development of hypertension and renal antioxidant/oxidant system in SHR and WKY rats. In the first stage of the study, blood pressure and antioxidant profiles in SHR and WKY rats were measured. After this the effect of cross-fostering was examined where one-day-old SHR and WKY pups were cross-fostered to the dam of the opposite strain and the male offspring were then raised up to 16 weeks of age. In the next stage, melatonin (10mg/kg body weight/day) was supplemented via drinking water to pregnant SHR/WKY from pregnancy day-1 and up to postpartum day-21, and then continued to be given to some of the weaned male offspring up to 16 weeks of age. In the following stage, one-day-old offspring of melatonin supplemented SHR and WKY dams were cross-fostered and after weaning some of these crossfostered male offspring continued to receive melatonin via drinking water up to 16 weeks of age. Systolic blood pressure (SBP) of all the male offspring was recorded at the age of 4, 6, 8, 12 and 16 weeks, and the kidneys were collected for the estimation of antioxidant/oxidant status at the end of each age category.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/8947
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectCross-Fostering And Melatonin Supplementationen_US
dc.subjectHypertensionen_US
dc.titleEffects Of Cross-Fostering And Melatonin Supplementation On The Development Of Hypertension And Renal Antioxidant/Oxidant System In Spontaneously Hypertensive Ratsen_US
dc.typeThesisen_US
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