Solid Phase Extraction Of Biogenic Amines Using Immobilized New Hydrazone Ligands
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Date
2011-02
Authors
Alfergani, Abdassalam Abdelhafiz
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
In this work, hydrazine and hydrazide compounds were subjected to condensation
reaction with ketone and different aldehyde derivatives affording the corresponding
expected hydrazones. All the ligands were isolated in satisfactory yields (82 - 94%).
Eight hydrazone ligands, namely, benzophenone - 2,4 - dinitrophenylhydrazone (HL1),
formaldehyde-2,4–dinitrophenylhydrazone (HL2), salicylaldehyde–2,4– dinitrophenylhydrazone
(HL3), 3-hydroxy-4-nitrobenzaldehyde-2,4-dinitrophenylhydrazone (HL4), 3-
hydroxy-4-nitrobenzaldehyde-4-hydroxybenzoylhydrazone (HL5), 2-hydroxy-5-nitrobenzaldehyde-
2,4-dinitrophenylhydrazone (HL6), 2-hydroxy-5-nitrobenzaldehyde-4-
hydroxybenzoylhydrazone (HL7) and salicylaldehyde-4-hydroxybenzoylhydrazone
(HL8) have been synthesized and characterized. Their chemical structures were found to
be consistent with both analytical and spectroscopic data (CHN, FTIR, UV/Vis, TGA and
1H NMR). The obtained ligands were evaluated for their anti-microbial activity towards
fungi, Aspergillus niger, Aspergillus flavus and Aspergillus fumigatus and bacteria,
Staphylooccus sp and Enterobacter sp. The results showed that these compounds are
mostly antibacterial rather than antifungal agents.
Description
Keywords
Biogenic Amines , Hydrazone Ligands